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Spring 2025
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Q&A

More time, more life

Why those with cancer—and their doctors—should consider the ‘time toxicity’ of treatment

Arjun Gupta, MD
ILLUSTRATION BY QUINCY SUTTON

There’s a quote from Henry David Thoreau that Arjun Gupta, MD, says guides his approach to cancer care: The price of anything is the amount of life you exchange for it.

Gupta, an M Health Fairview gastrointestinal oncologist, says that despite their best intentions, cancer doctors don’t always fully appreciate how much time—and life—a person spends being treated for cancer. It’s more than the time spent at a clinic visit or a chemotherapy appointment, he says. It’s the time spent driving to the hospital, waiting to see the doctor, recovering from treatment, talking on the phone with insurance providers—the time spent not enjoying life.

In 2022, Gupta coined the term “time toxicity” as a first step in identifying and quantifying the time cost of receiving cancer treatment. Based on his research, which is supported by philanthropy, he argues that the time commitments associated with cancer care—just like the physical toll of certain drugs and the financial burdens of treatment—should be considered when creating a person’s care plan.

“It’s our responsibility to make sure that patients and their loved ones can spend their precious time doing the things they love,” he says.

How do you measure time in the context of a cancer diagnosis? 

We interviewed patients, their loved ones, and members of their care team to figure out what time commitments felt burdensome. One theme emerged: Any time a person has to get out of their pajamas, get into the car, come to the clinic or the hospital for any amount of time—that can take up their whole day. We call these days “health care contact days.”

How do you talk about “contact days” with patients and their families? 

We recognize that not all contact days are equally burdensome and that not all contact days are bad, right? It depends on each individual. So I can say to a person, “With treatment A, you will have 15 contact days in the next month, and with treatment B, you will have five contact days.” Treatment B may not technically offer the same survival benefits as treatment A, but it’s less of a time commitment. And so people can then apply their own values and lifestyle to those numbers.

What does that look like in practice? 

Maybe one person lives next to the cancer center and they enjoy visits to the clinic; these visits are a kind of social outing. For them, more contact days might be a good thing. But maybe another person lives hundreds of miles away and even a single contact day in a month is a lot. It’s all about asking the person what they want their care to look like, giving them the information, and allowing them to make the most informed choice.


Weighing the time cost of care
When it comes to cancer drugs, new isn’t always better, says Arjun Gupta, MD.

Especially for people diagnosed with advanced cancers, the promise that a new drug could extend life by a few weeks or months might not be worth the time commitment and side effects that are associated with it.

“I think we in oncology sometimes celebrate very modest advancements,” Gupta says. “We say, ‘Oh wow, we have a new drug that improves survival by three weeks,’ which sounds good. And it is great for patients to have access to more treatment options! But the reality is that the side effects and time commitment to receive this drug can actually outweigh those potential benefits.”

In these scenarios, he and his team explain to patients the time commitments associated with treatment options—dividing days between “home days,” which are spent doing what people want to do, and “health care contact days,” which involve coming back and forth to the clinic. It’s an easy-to-understand metric (see graphic above) that allows people and their loved ones to make informed decisions about how they want to spend their time.

“Our goal is to give people all the information they need to feel empowered and make the choice that’s best for them,” Gupta says. “I think that’s a real cultural shift in cancer care.”
ISTOCK IMAGES: DENIS NOVIKOV, MAULANA AHSAN, RUDZHAN NAGIEV

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